Effects of Replacing Solid Fats and Added Sugars with Avocado in Adults with Elevated Cardiometabolic Risk: A Randomized, Double-Blind, Controlled Feeding, Crossover Trial - CV Wellness

avocado convo bug

Replacing saturated fats and added sugars with one avocado lowered triglycerides by 17.4% (p < 0.001).1

Study Evaluates Avocado-Containing Diets on Cardiometabolic Risk Factors

Research Summary

In a randomized, double-blind, crossover feeding trial, 42 adults with elevated triglycerides followed two 3-week diets: one where a daily Hass avocado replaced solid fats and added sugars, and a matched control diet.

    The avocado diet lowered:

  • non-HDL cholesterol by 4.65% (p = 0.047)
  • VLDL cholesterol by 9.30% (p = 0.007)
  • and triglycerides by 17.4% (p < 0.001)

Funded by the Avocado Nutrition Center, the study found replacing solid fats and added sugars with avocado in a typical American diet improved the lipoprotein lipid profile in adults with elevated triglycerides. However, the results cannot be generalized to larger, more diverse populations.

Download the fact sheet to learn more about the growing body of evidence exploring how avocado consumption fits into a heart-healthy eating pattern that supports cardiovascular health.

Download Fact Sheet

Updated with the latest research!

1 Gletsu-Miller, N., et. Al. “Effects of Replacing Solid Fats and Added Sugars with Avocado in Adults with Elevated Cardiometabolic Risk: A Randomized, Double-Blind, Controlled Feeding, Crossover Trial.” The American Journal of Clinical Nutrition. 2026.

salad with avocado

Thumbnail of handout for Large Prospective Study Links Avocado Intake and Lower Cardiovascular Disease

Avocados and Cardiovascular Health:

Clinical Resource Guide

This guide highlights findings from a large prospective study linking regular avocado intake with lower cardiovascular disease risk, and translates the evidence into practical, heart-healthy counseling tips and recommendations for patients.

Download Handout

Quick Ways to Start the Conversation

Use these patient-friendly resources to guide meaningful conversations about improving cardiovascular health through simple, sustainable nutrition changes.

Thumbnail graphic for Easy 3-Day Heart Healthy Meal Plan

Tips for Lowering Cardiometabolic Risk

Thumbnail of Heart Health Toolkit

Nutrition Resource

Heart Health Toolkit

Large Prospective Study Links Avocado Intake and Lower Cardiovascular Disease

Heart Health Mini Cookbook

Avocado-Inspired Recipes

Help your patients enjoy the nutritional benefits of fresh avocados with this collection of heart-healthy recipes.

Download Cookbook

More Ways to Enjoy Heart-Healthy Avocados

Fresh avocados bring versatility to heart-healthy eating and can even be frozen for later use, making it easy to keep this nutrient-dense fruit on hand. Share these two delicious recipes with patients: a satisfying dinner option and a frozen dessert treat.

Heart-Healthy Avocado Banana Ice Cream

Heart-Healthy Avocado Banana “Ice Cream”

View Recipe →

Heart-Healthy Fettuccini AvoFredo

Heart-Healthy Fettuccini AvoFredo

View Recipe →

Recommend Heart-Healthy Avocados

Avocados deliver a powerful combination of fiber and naturally good fats that align with heart-healthy dietary recommendations. Share these key benefits with patients and recommend avocados as part of a nutritious, balanced diet.

avocado icon

The American Heart Association recommends replacing saturated fats with unsaturated fats for heart health. Avocados are low in saturated fat and provide 6 grams of unsaturated fat per serving (one-third of a medium avocado).

fiber icon

Fiber is emphasized in dietary guidance for both cardiovascular health and type 2 diabetes. Avocados provide 3 grams of fiber per serving and can help patients increase fiber intake.

checkboard icon

Encouraging a variety of nutrient-dense fruits supports cardiovascular health. Heart-healthy avocados are a nutrient-dense option to help meet that goal.